A Hospital Based Comparative Clinical study between Mometasone Furoate and Fluticasone Furoate Nasal Spray for Allergic Rhinitis

Introduction: Allergic rhinitis is an inflammatory disorder of the nose which occurs when the membranes lining the nose become sensitised to allergens. Although not classed as a life-threatening disease, allergic rhinitis can reduce the patient’s quality of life. Mometasonefuroate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. It is a prodrug of the free form mometasone. Fluticasonefuroate is a synthetic corticosteroid with a very high affinity for the glucocorticoid receptor and has a potent antiinflammatory action. Aim: Tocompare clinicaleffects between mometasonefuroate and fluticasonefuroate nasal spray for allergic rhinitis Results: Two hundred fifty-nine patients were valid for efficacy. Mometasonefuroate was significantly more effective than placebo and was not different from fluticasonefuroate . The study was also physician-evaluated for total nasal symptoms. Overall, mometasonefuroate was at least as effective as fluticasonefuroate at equivalent doses. Conclusion:Mometasonefuroate and fluticasonefuroate adequately controlled symptoms of perennial rhinitis and were well tolerated. Source Of Support : Nil Conflict Of Interest: Nil